110072-15-6

Tosagestin(Org 30659) is a 19-nortestosterone–derived progestagen. Tosagestinsuppresses ovarian function to a level sufficient to inhibit ovulation. Tosagestininhibits cell growth in T47D-S cells[1][2].

[1] Schoonen WG, et al. Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: II. T47D cell lines. J Steroid Biochem Mol Biol. 1995;55(3-4):439-444. 、 DOI:10.1016/0960-0760(95)00216-2
[2] Obruca A, et al. Ovarian function during and after treatment with the new progestagen Org 30659. Fertil Steril. 2001;76(1):108-115. DOI:10.1016/s0015-0282(01)01824-6