1095173-64-0

Name	1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea
CAS	1095173-64-0
Molecular Formula	C21H23ClN6O
Molecular Weight	410.91
MOL File	1095173-64-0.mol

Synonyms

EOS-62277 Glasdegib hydrochloride 1-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-3-(4-cyanophenyl)urea hydrochloride 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea hydrochloride Urea, N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N'-(4-cyanophenyl)-, hydrochloride (1:1)

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Hazard Information

Uses

Glasdegib hydrochloride is a potent and orally bioavailable smoothened inhibitor. Glasdegib hydrochloride (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM[1].

References

[1] Sadarangani A, et al. GLI2 inhibition abrogates human leukemia stem cell dormancy. J Transl Med. 2015 Mar 21;13:98. DOI:10.1186/s12967-015-0453-9

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Haiji Pharmaceutical Technology (Suzhou) Co., Ltd

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TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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