108427-72-1

Name	AS 35
CAS	108427-72-1
Molecular Formula	C21H20N6O4
MDL Number	MFCD00892239
Molecular Weight	420.42
MOL File	108427-72-1.mol

Synonyms

AS 35 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-[(4-acetyl-3-hydroxy-2-propylphenoxy)methyl]-3-(2H-tetrazol-5-yl)- 3-(1H-Tetrazol-5-yl)-9-[[[2-propyl-3-hydroxy-4-(methylcarbonyl)phenyl]oxy]methyl]-4H-pyrido[1,2-a]pyrimidin-4-one

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Chemical Properties

Melting point	269-271 °C
Boiling point	678.8±65.0 °C(Predicted)
density	1.46±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	3?+-.0.10(Predicted)

Hazard Information

Uses

AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50 values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities.

in vivo

AS-35 (0.0375 to 0.3 mg/kg, i.v.) dose-dependently antagonizes bronchoconstriction induced by i.v.-injection of LTC4 and LTD4 in anesthetized guinea pigs, but does not inhibit histamine-induced bronchoconstriction. Oral administration of AS-35 also antagonizes LTD4 as well as antigen-induced LT-mediated bronchoconstriction. AS-35 (p.o.) inhibits LTD4-induced increase in the cutaneous vascular permeability of guinea pig^[1].

IC 50

LTE₄: 3 nM (IC₅₀, In isolated guinea pig ileum); LTD₄: 4 nM (IC₅₀, In isolated guinea pig ileum); LTC₄: 8 nM (IC₅₀, In isolated guinea pig ileum)

References

[1] Kasai H, et al. Peptide leukotriene antagonistic activity of AS-35, a new antiallergic drug. Jpn J Pharmacol. 1992 Apr;58(4):347-55. DOI:10.1254/jjp.58.347

Supplier

Fan De(Beijing) Biotechnology Co., Ltd.

Telephone 15911056312

Websitehttp://www.bio-fount.com/

TargetMol Chemicals Inc.

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Websitehttps://www.targetmol.cn/

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Shanghai Amole Biotechnology Co., Ltd.

Telephone13370042665 18916960931

Websitehttps://www.amole.com.cn/

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