1082041-79-9

116409-35-9

1082041-79-9

8-Methylisoquinolin-1(2H)-one (76a, 1 g, 6.29 mmol) was used as raw material and mixed with 10% Pd/C (0.5 g) in methanol (20 mL). The mixture was subjected to hydrogenation reaction under hydrogen (60 psi) atmosphere at 80°C for 48 hours. Upon completion of the reaction, the reaction mixture was filtered and the solid catalyst was washed with methanol (2 x 20 mL). The filtrate was concentrated under vacuum to afford the target product 8-methyl-3,4-dihydroisoquinolin-1(2H)-one (76b, 1 g, ~100% yield) as a gray solid.