107978-83-6

REDV is the minimal active sequence within the CS5 site of the alternatively spliced type III connecting segment (IIICS) region of fibronectin. REDV can mediate adhesion to the IIICS region of plasma fibronectin by binding the integrin alpha 4 beta 1(α4β1). REDV can be used for the research of cell adhesion. REDV is used to study the effects of gene vectors containing REDV on cells[1][2].

[1] S P Massia, et al. Vascular endothelial cell adhesion and spreading promoted by the peptide REDV of the IIICS region of plasma fibronectin is mediated by integrin alpha 4 beta 1. J Biol Chem. 1992 Jul 15;267(20):14019-26. PMID:1629200
[2] Lv J, et al. Star-shaped copolymer grafted PEI and REDV as a gene carrier to improve migration of endothelial cells. Biomater Sci. 2017 Feb 28;5(3):511-522. DOI:10.1039/c6bm00856a