1071000-98-0

Name	FKGK 11
CAS	1071000-98-0
Molecular Formula	C13H13F5O
MDL Number	MFCD18382097
Molecular Weight	280.23
MOL File	1071000-98-0.mol

Synonyms

FKGK 11 FKGK11 >=98% (GC) 1,1,1,2,2-Pentafluoro-7-phenyl-3-Heptanone 1,1,1,2,2-pentafluoro-7-phenylheptan-3-one 3-Heptanone, 1,1,1,2,2-pentafluoro-7-phenyl-

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Chemical Properties

Boiling point	288.9±40.0 °C(Predicted)
density	1.222±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 2 mg/ml
form	oil
color	colorless to yellow

Safety Data

WGK Germany

Hazard Information

Uses

FKGK11 is a potent and selective inhibitor of GVIA iPLA2 (Group VIA calcium-independent phospholipase A2). FKGK11 can be used for the research of ovarian cancer and neurological disorders such as peripheral nerve injury and multiple sclerosis[1][2].

Definition

ChEBI: FKGK 11 is a member of benzenes.

in vivo

FKGK11 inhibits tumor development in the xenograft mouse model^[2].
FKGK11 shows a significant increase in the number of macrophages and degenerating fibres with disrupted myelin sheaths in cPLA2 GIVA?/? mice and C57BL/6 mice^[3].

IC 50

PLA2

References

[1] Kokotos G, et al. Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10. DOI:10.1021/jm901872v
[2] Yan Xu, et al. Abstract 3525: Targeting Group VIA phospholipase A2 using small molecules for ovarian cancer treatment. Cancer Res (2011) 71 (8_Supplement): 3525.
[3] López-Vales R, et al. Intracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury. Brain. 2008 Oct;131(Pt 10):2620-31. DOI:10.1093/brain/awn188

Supplier

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Shanghai Hongye Biotechnology Co. Ltd

Telephone400-9205774 400-920-5774

Websitehttp://www.glpbio.cn/

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Telephone 18818260767

Websitehttp://www.chemegen.com

Energy Chemical

Telephone400-0056266

Websitehttp://www.energy-chemical.com

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

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