106807-72-1

White to Off-White Crystalline Solid

a2-Adrenergic aginist. Sedative; analgesic

Potent, highly selective α 2 -adrenoceptor agonist (K i values are 1.08 and 1750 nM for α 2 - and α 1 -adrenoceptors respectively). Displays greater selectivity over α 1 -adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Inhibits twitch response in electrically stimulated mouse vas deferens (pD 2 = 9.0). Active in vivo ; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

ChEBI: Medetomidine hydrochloride is a hydrochloride.