106134-33-2

Ro 22-9194 is a new class I antiarrhythmic agent. Ro 22-9194 (?10 μM) caused a concentration-dependent decrease in the maximum upstroke velocity (V?max) and shortening of action potential duration in guinea-pig ventricular cells.

Ro 22-9194 inhibits aggregation and thromboxane Az (TXA2) synthetase activity in rabbit and human platelets. Ro 22-9194 has a potent inhibitory action against various types of model arrhythmias. Ro 22-9194 has non-cholinergic cardiac depressant properties with its vasodilating action[1][2].

[1] M Murakami, et al. Cardiovascular effects of 2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide dihydrochloride (Ro 22-9194) in the isolated, cross-perfused atrium of the dog. Jpn Heart J. 1990 Sep;31(5):731-9. DOI:10.1536/ihj.31.731
[2] I Kodama, et al. Electropharmacology of Ro 22-9194, a new antiarrhythmic agent. Gen Pharmacol. 1996 Jul;27(5):755-60. DOI:10.1016/0306-3623(95)02094-2