106032-59-1

D-myo-Inositol-1-phosphate (Ins(1)P1) is a member of the inositol phosphate molecular family of second messengers that play critical roles in intracellular signaling.1,2 Ins(1)P1 can be formed by PLC hydrolysis of phosphatidylinositol or by dephosphorylation of polyphosphate inositols such as Ins(1,3)P2 by inositol polyphosphate 3-phosphatase.1 Changes in myo-inositol-1-phosphate synthase activity and inositol levels are induced by lithium and valproate and are associated with bipolar disorder.3,4 Also, cross-regulation occurs between the SUMO and inositol pathways.5WARNING This product is not for human or veterinary use.

[1] MAJERUS P W. Inositol phosphate biochemistry.[J]. Annual review of biochemistry, 1992, 61: 225-250. DOI: 10.1146/annurev.bi.61.070192.001301
[2] BERRIDGE M J. Inositol trisphosphate and calcium signalling[J]. Nature, 1993, 361 6410: 315-325. DOI: 10.1038/361315a0
[3] ALON SHAMIR. Human MIP synthase splice variants in bipolar disorder[J]. Bipolar Disorders, 2007, 9 7: 766-771. DOI: 10.1111/j.1399-5618.2007.00440.x
[4] LORETTA M. HALLCHERS W S. The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.[J]. The Journal of Biological Chemistry, 1980, 28 1: 10896-10901. DOI: 10.1016/s0021-9258(19)70391-3
[5] RACHAEL FELBERBAUM. Desumoylation of the endoplasmic reticulum membrane VAP family protein Scs2 by Ulp1 and SUMO regulation of the inositol synthesis pathway.[J]. Molecular and Cellular Biology, 2012, 32 1: 64-75. DOI: 10.1128/mcb.05878-11