Reactivity Profile
Di-t-butylmethylsilyl Trifluoromethanesulfonate is a bulky trialkylsilylating agent, useful for the preparation of hydrolytically stable, sterically congested enol silyl ethers and silyl carboxylic esters; t-Bu2MeSi- also serves as a reactivity control element.
Synthesis
The preparative method of Di-t-butylmethylsilyl Trifluoromethanesulfonate: addition of Trifluoromethanesulfonic Acid (TfOH) to neat di-t-butylmethylsilane2 at 4 °C, stirring 16 h at 20 °C, followed by distillation in vacuo.
Precautions
Stable in the absence of moisture. Fumes in moist air produce TfOH by hydrolysis. Owing to the high corrosivity of TfOH, breathing the vapor or the fumes produced by reaction with moist air should be avoided. Use in a fume hood.
