Uses
AKR1C3-IN-14 (compound 4) is an AKR1C3 inhibitor (IC50=0.122 μM) that reduces the overproduction of androgens by inhibiting the activity of the AKR1C3 enzyme, thereby regulating hormone-mediated signaling. AKR1C3-IN-14 also plays a role in the biosynthesis of the prostaglandin PGF2α, regulating cell proliferation by affecting this pathway. AKR1C3-IN-14 can be used in the study of prostate cancer[1].
References
[1] Pippione A C, et al. AI Based Discovery of a New AKR1C3 Inhibitor for Anticancer Applications[J]. ACS Medicinal Chemistry Letters, 2024.
