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Skeletal muscle relaxant

Azumolene is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. It inhibits a component of store-operated calcium entry (SOCE) that is coupled to the skeletal muscle ryanodine receptor, with 20 μM azumolene causing a 70% reduction in SOCE in myotubes. Azumolene has utility in countering muscle dysfunction associated with malignant hyperthermia.

ChEBI: Azumolene sodium is the anhydrous sodium salt of azumolene. It contains an azumolene(1-).

[1] S S PALNITKAR. Pharmacological distinction between dantrolene and ryanodine binding sites: evidence from normal and malignant hyperthermia-susceptible porcine skeletal muscle.[J]. Biochemical Journal, 1997, 326 ( Pt 3): 847-852. DOI: 10.1042/bj3260847
[2] G.C. LESLIE  N. J P. The effect of EU4093 (azumolene sodium) on the contraction of intrafusal muscle in the soleus muscle of the anaesthetized rat[J]. British Journal of Pharmacology, 1989, 97 4: 1151-1156. DOI: 10.1111/j.1476-5381.1989.tb12573.x
[3] XIAOLI ZHAO. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor.[J]. The Journal of Biological Chemistry, 2006, 281 44: 33477-33486. DOI: 10.1074/jbc.m602306200
[4] VIKTOR YAROTSKYY R T D Feliciano Protasi. Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death.[J]. PLoS ONE, 2013: e77633. DOI: 10.1371/journal.pone.0077633