105102-21-4

Name	Torbafylline
CAS	105102-21-4
Molecular Formula	C16H26N4O4
MDL Number	MFCD00867585
Molecular Weight	338.4
MOL File	105102-21-4.mol

Synonyms

HWA-448 Torbafylline 7-(Ethoxymethyl)-1-(5-hydroxy-5-methylhexyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione 1H-Purine-2,6-dione, 7-(ethoxymethyl)-3,7-dihydro-1-(5-hydroxy-5-methylhexyl)-3-methyl-

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Chemical Properties

Boiling point	534.7±60.0 °C(Predicted)
density	1.25±0.1 g/cm3(Predicted)
pka	15.28±0.29(Predicted)

Hazard Information

Uses

Torbafylline is a PDE inhibitor. Torbafylline mitigates protein breakdown in rat skeletal muscle following burns by activating the PDE4/cAMP/EPAC/PI3K/Akt signaling pathway. Torbafylline suppresses the increased ubiquitin-proteasome-dependent protein degradation observed in the skeletal muscles of rats susceptible to cancer and sepsis[1].

References

[1] Okyayuz-Baklouti I. The effects of torbafylline on blood flow, pO2 and function of rat ischaemic skeletal muscle. Eur J Pharmacol. 1989 Jul 4;166(1):75-86. DOI:10.1016/0014-2999(89)90685-7

Supplier

Jinan ponder chemical co. LTD

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Websitehttps://www.chemicalbook.com/ShowSupplierProductsList546697/0.htm

Shanghai Dexuan Pharmaceutical Technology Co., Ltd

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Websitehttps://www.chemicalbook.com/ShowSupplierProductsList182151/0.htm

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Sangon Biotech (Shanghai) Co.,Ltd.

Telephone400-821-026

Websitehttp://www.sangon.com

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