104186-68-7

Methoxycarbonyl-D-Nle-Gly-Arg-pNA is a synthetic trypsin that can serve as a substrate for coagulation factors IXa (FIXa) and Xa (FXa)[1][2][3].

[1] Hopfner KP, et al. New enzyme lineages by subdomain shuffling. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9813-8. DOI:10.1073/pnas.95.17.9813
[2] Hopfner KP, et al. Converting blood coagulation factor IXa into factor Xa: dramatic increase in amidolytic activity identifies important active site determinants. EMBO J. 1997 Nov 17;16(22):6626-35. DOI:10.1093/emboj/16.22.6626
[3] Sturzebecher J, et al. Dramatic enhancement of the catalytic activity of coagulation factor IXa by alcohols. FEBS Lett. 1997 Jul 28;412(2):295-300. DOI:10.1016/s0014-5793(97)00811-9