104073-72-5

Name	YM 16638
CAS	104073-72-5
Molecular Formula	C18H22N2O5S3
MDL Number	MFCD01751276
Molecular Weight	442.57
MOL File	104073-72-5.mol

Synonyms

YM-638 YM 16638 YM 638|||YM-16638|||YM16638 [[5-[[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propyl]thio]-1,3,4-thiadiazol-2-yl]thio]acetic acid Acetic acid, 2-[[5-[[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl]thio]-1,3,4-thiadiazol-2-yl]thio]- 2-[[5-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propylsulfanyl]-1,3,4-thiadiazol-2-yl]sulfanyl]acetic acid

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Chemical Properties

Melting point	129-130 °C
Boiling point	682.6±65.0 °C(Predicted)
density	1.42±0.1 g/cm3(Predicted)
pka	2.87±0.10(Predicted)

Hazard Information

Uses

YM-16638 is an orally active leukotriene (LT) antagonist. YM-16638 can inhibit the production of LTC4, LTD4, and LTE4 in guinea pig trachea, with IC50 values of 0.05 μM, 0.16 μM, and 0.096 μM, respectively. YM-16638 has a dose-dependent inhibitory effect on antigen-induced early and late respiratory responses in allergic sheep[1].

References

[1] Tomioka K, et al. The effect of an orally active leukotriene (LT) antagonist YM-16638 on antigen-induced early and late airway responses in allergic sheep. Prostaglandins Leukot Essent Fatty Acids. 1989 Apr;36(1):43-7. DOI:10.1016/0952-3278(89)90161-0

Spectrum Detail

YM 16638(104073-72-5)¹HNMR

Supplier

Shanghai Dexuan Pharmaceutical Technology Co., Ltd

Telephonedexuanyiyao@126.com

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList182151/0_EN.htm

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Shanghai Amole Biotechnology Co., Ltd.

Telephone13370042665 18916960931

Websitehttps://www.amole.com.cn/

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