10405-27-3

Difluoroamine is used as a reagent for introducing difluoroamine groups into organic molecules; synthesis of diazirines; deamination of primary amines.

Difluoramine can be generated from tetrafluorohydrazine, which is made by reaction of NF3 with various metals at 375 °C.^[1] Conversion into difluoramine is accomplished by heating tetrafluorohydrazine with Thiophenol in an evacuated bulb.^[2] Difluoramine is also generated by heating N,N-difluorourea with conc. Sulfuric Acid.^[3]

Difluoroamine is shock sensitive. Reactions should be carried out in a fume hood.

1. Colburn, C. B.; Kennedy, A. JACS 1958, 80, 5004.
2. Freeman, J. P.; Kennedy, A.; Colburn, C. B. JACS 1960, 82, 5304.
3. Mueller, K. F.; Cziesla, M. J. JOC 1969, 34, 917.