1038408-36-4

1038408-35-3

64-19-7

1038408-36-4

Part D: 5-Bromo-N1-isopropyl-1,2-benzenediamine (0.56 g, 2.45 mmol) was dissolved in glacial acetic acid (20 mL), heated to reflux and stirred for 2 hours. The completion of the reaction was confirmed by LC-MS analysis. The reaction mixture was concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography (eluent: 5% methanol/dichloromethane) to afford 6-bromo-1-isopropyl-2-methyl-1H-benzo[d]imidazole (Compound 227) as a red oil in a yield of 0.55 g (90%).1H NMR (400 MHz, DMSO-d6) δ 7.82 (d,1H), 7.44 (1H) 7.24 (dd, 1H), 4.75 (m, 1H), 2.54 (s, 3H), 1.51 (d, 6H).