103379-03-9

Name	monatepil
CAS	103379-03-9
Molecular Formula	C32H34FN3O5S
Molecular Weight	591.7
MOL File	103379-03-9.mol

Synonyms

show less show more

Chemical Properties

Melting point

149-150°

Safety Data

Toxicity

LD50 in mice (g/kg): >1 i.p.; >4 orally (Uno)

less more

Hazard Information

Uses

Monatepil maleate (AJ-2615) is a potent and orally active Ca2+-channel antagonist and a noncompetitive ACAT inhibitor. Monatepil maleate decreases blood pressure and improves plasma lipid metabolism. Monatepil maleate has the potential for the research of hyperlipidemia[1][2].

Definition

ChEBI: Monatepil maleate is a dibenzothiepine.

in vivo

Monatepil maleate (30 mg/kg; p.o.; once daily for 9 weeks) improves plasma lipid metabolism^[1].
Monatepil maleate (30 mg/kg; p.o.; once daily for 6 weeks) inhibits ACAT activity and esterifies cholesterol content in high cholesterol diet monkeys^[2].

Animal Model:	8 weeks, Male japanese white rabbits (high cholesterol diet-fed)^[1]
Dosage:	30 mg/kg
Administration:	P.o.; once daily for 9 weeks
Result:	Improved plasma lipid metabolism and reduced atherosclerotic lesions, decreased blood pressure.

Animal Model:	4-7 kg, 4-7 years monkeys (high cholesterol diet for 6 months)^[2]
Dosage:	30 mg/kg
Administration:	P.o.; once daily for 6 weeks
Result:	Inhibited the increases of ACAT activity and esterified cholesterol content.

References

[1] Ikeno A, et al. Effects of monatepil maleate, a new Ca2+ channel antagonist with alpha1-adrenoceptor antagonistic activity, on cholesterol absorption and catabolism in high cholesterol diet-fed rabbits. Jpn J Pharmacol. 1998 Nov;78(3):303-12. DOI:10.1254/jjp.78.303
[2] Sumiya T, et al. Inhibitory effect of monatepil maleate on acyl-CoA:cholesterol acyltransferase activity in the liver of cholesterol-fed Japanese monkeys. Am J Hypertens. 1997 Jul;10(7 Pt 1):779-85. DOI:10.1016/s0895-7061(97)00066-6

Supplier

Shanghai Dexuan Pharmaceutical Technology Co., Ltd

Telephone 1701086315

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList182151/0.htm

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

PROMPT×

PROMPT
The What'sApp is temporarily not supported in mainland China

Cancel

Determine

Send Inquriy