PX-866-17OH is an active metabolite of PX-866 (Item No. 13645).1 It inhibits PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ (IC50s = 14, 57, 131, and 148 nM, respectively).
Uses
PX-866-17OH is the metabolite of PX-866 (Sonolisib, HY-N6775) and a pan-isoform inhibitor of PI3K with IC50s of 14, 57, 131, and 148 nM against PI3Kα, PI3Kβ, PI3K , and PI3Kδ, respectively[1].
References
[1] Zask A, et al. Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy. J Med Chem. 2008 Mar 13;51(5):1319-23. DOI:10.1021/jm7012858
