101184-08-1

288-32-4

403-33-8

101184-08-1

General procedure for the synthesis of methyl 4-(1H-imidazol-1-yl)benzoate from imidazole and methyl 4-fluorobenzoate: imidazole (132 g, 1.9 mol), methyl 4-fluorobenzoate (170 ml, 1.3 mol) and potassium carbonate (357 g, 2.6 mol) were dissolved in DMSO (200 ml) to form a reaction mixture. The reaction mixture was stirred at 120°C for 3 hours. After completion of the reaction, it was cooled to room temperature and the mixture was poured into cold water. The solid product precipitated was collected by filtration and washed with cold water. The yield of the final product was 59%.