LY 186126 is a potent cGI-PDE inhibitor. It exhibit reversible, high affinity (Ka = 6 nM) binding to a single class of SaR binding sites.
Uses
LY 186126 a Indolidan analog, is a phosphodiesterase (PDE) inhibitor. LY 186126 binds to cardiac sarcoplasmic reticulum PDE with high affinity, with a Kd of 5.6 nM[1].
References
[1] T Ashikaga, et al. Comparison of indolidan analog binding sites of drug antibody and sarcoplasmic reticulum with inhibition of cyclic AMP phosphodiesterase. J Recept Signal Transduct Res. 1996 Sep-Nov;16(5-6):315-37. DOI:10.3109/10799899609039954
