20(s)-原人参三醇
20(s)-原人参三醇 性质
| 熔点 | 242-244 °C |
|---|---|
| 沸点 | 590.0±50.0 °C(Predicted) |
| 密度 | 1.079 |
| 储存条件 | -20°C Freezer |
| 溶解度 | 可溶于氯仿（少许）、DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.73±0.70(Predicted) |
| 颜色 | 米白色 |
| LogP | 5.890 (est) |
20(s)-原人参三醇 用途与合成方法
Glucocorticoid receptor, Oestrogen receptor, LXRα
(20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and oestrogen receptor (ER) in human umbilical vein endothelial cells (HUVECs). (20S)-Protopanaxatriol (g-PPT) increases [Ca 2+ ] i with an EC 50 of 482 nM in HUVECs. (20S)-Protopanaxatriol (1 µM) elevates NO production via ERβ. (20S)-Protopanaxatriol (PPT) inhibits the autonomous transactivation of Gal4-LXRα LBD, the T0901317-dependent transcription of SREBP-1c and its promoter. (20S)-Protopanaxatriol (10 μg/mL) blocks the recruitment of RNA polymerase II to the LXRE region of SREBP-1c. (20S)-Protopanaxatriol also inhibits T0901317-dependent transcription of LXRα target genes related to lipogenesis, and reduces T0901317-induced cellular triglyceride (TG) accumulation in primary hepatocytes, but does not alter transcription of ABCA1, also an LXRα target gene.
药理药效:原人参三醇型皂苷可以体外协同抗原负载诱导小鼠骨髓细胞的树突状细胞成熟，发挥对肿瘤细胞的特异细胞毒作用；其次，PPT型皂苷注射液能明显改善大脑中动脉阻塞(MCAO)大鼠的偏瘫体征、缩小脑内梗死面积、缓解脑水肿症状。
20(s)-原人参三醇 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-16 | S3617 | 20(s)-原人参三醇 | 34080-08-5 | 5mg | 794.62 |
| 2024-01-16 | S3617 | 20(s)-原人参三醇 | 34080-08-5 | 25mg | 2023.18 |
