N,N'-ジシクロヘキシルチオ尿素

外観

白色～ほとんど白色粉末～結晶

使用

1,3-Dicyclohexylthiourea is used in the evaluation of its sensitivity, specificity and relative predictivity of battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens.

一般的な説明

White crystals.

空気と水の反応

1,3-Dicyclohexylthiourea may be sensitive to prolonged exposure to air. Insoluble in water.

反応プロフィール

1,3-Dicyclohexylthiourea is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). 1,3-Dicyclohexylthiourea is incompatible with acids and oxidizing agents. 1,3-Dicyclohexylthiourea reacts with water.

健康ハザード

ACUTE/CHRONIC HAZARDS: When heated to decomposition 1,3-Dicyclohexylthiourea emits very toxic fumes.

火災危険

Flash point data for 1,3-Dicyclohexylthiourea are not available. 1,3-Dicyclohexylthiourea is probably combustible.

用途

縮合剤であるN,N'-ジシクロヘキシルカルボジイミド（DCC）の原料

合成方法

(Synthetic Communications, 2009, 39, 2093)
(Synthetic Communications, 2006, 36, 1787)