クリンバゾール

外観

白色～ほとんど白色粉末～結晶

定義

本品は、次の化学式で表される複素環式化合物である。

化粧品の成分用途

殺菌剤

説明

(±)-Climbazole is an imidazole antifungal agent. It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro. It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo. (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver. Formulations containing climbazole have been used in the treatment of dandruff.

化学的特性

White Solid

使用

Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. s assay and did not induce micronuclei in human lymphocytes.

危険性

Moderately toxic by ingestion. Low toxicity by skin contact.

副作用

May cause localized irritation of the skin with symptoms including redness, rashes and itching.