4-[[(3S)-3-アミノ-5-(アミジノメチルアミノ)-1-オキソペンチル]アミノ]-1-(4-アミノ-2-オキソ-1(2H)-ピリミジニル)-1,2,3,4-テトラデオキシ-β-D-erythro-2-ヘキセノピラヌロン酸·塩酸塩

外観

白色～ほとんど白色、結晶性粉末～粉末

溶解性

水に可溶

化学的特性

White powder

使用

Blasticidin S hydrochloride is a salt of blasticidin S, an amphoteric nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S hydrochloride was originally isolated fby acetone precipitation. For historical reasons only the salt has been routinely available to researchers. Both the salt and free base are freely water soluble. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations.

一般的な説明

Nucleoside antibiotic that specifically inhibits protein synthesis in both prokaryotes and eukaryotes. Suitable for selection of cells carrying plasmids conferring blasticidin resistance. Blasticidin resistance is conferred by the blasticidin S deaminase gene (bsr) that converts blastisidin S to a nontoxic deaminohydroxy derivative.