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外観
白色〜ほとんど白色, 結晶〜粉末
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溶解性
エタノールに溶けやすく、水に溶けにくい。
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用途
白癬菌、真菌などに抗菌作用
を示します。
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用途
白癬菌、真菌等に抗菌作用を
示します。
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効能
抗真菌薬, エルゴステロール合成阻害薬
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商品名
ボレー (久光製薬); ボレー (久光製薬); メンタックス (科研製薬)
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説明
Butenafine hydrochloride is a new benzylamine antifungal which appears to block the
squalene epoxidation step of sterol synthesis in fungi. Active against a broad spectrum
of fungi, butenafine hydrochloride is more effective in a guinea-pig model of tinea
pedis than clotrimazole, naftifine and tolnaftate. Its efficacy is partially attributed to its
long retention time in the skin.
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化学的特性
White Solid
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使用
Butenafine hydrochloride has been used as a standard in high-performance liquid chromatography (HPLC) method to determine butenafine hydrochloride in butenafine-loaded nanosponges.
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定義
ChEBI: The hydrochloride salt of butenafine. An inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, it is used for treatment of dermatological fungal infections.
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一般的な説明
Butenafine hydrochloride is chemically known as N-4-tertbutylbenzyl-N-methyl-1-naphthalenemethylamine hydrochloride. Butenafine, a benzylamine derivative, is a new generation antimycotic compound. It is easily soluble in methanol, ethanol, dichloromethane, and chloroform, but not in water. The allyl radical in butenafine hydrochloride is substituted by a butylbenzyl group.
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副作用
Side Effects:
Blistering, burning, crusting, dryness, or flaking of the skin where the medicine is applied.
itching, scaling, severe redness, soreness, or swelling of the skin where the medicine is applied.
