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外観
暗紫青色〜暗赤紫色, 粉末又は塊
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定義
本品は、平成15年厚労省令第126号に示される青色2号又はそのアルミニウムレーキである。
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溶解性
水にやや溶けにくく、エタノール（99.5）及びジエチルエーテルにほとんど溶けない。
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解説
C16H8N2Na2O8S2(466.36)．インジゴカルミン，C.I.Food Blue 1ともいう．インジゴを濃硫酸のみまたは発煙硫酸を併用してスルホン化後，ナトリウム塩として得る．
"暗青色の粉末．水溶液は青～青紫色を呈する．λmax 612 nm(水)．光，熱に弱く，還元すると無色のロイコ酸になる．酸化還元指示薬，食品の着色料に用いられる．LD50 ＞ 2500 mg および405 mg/kg(マウス，経口および皮下)．[CAS 860-22-0]
森北出版「化学辞典（第2版）
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用途
硝酸塩等の酸化剤の試験用。
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用途
染料、指示薬(酸化還元、pH)、酸化剤(硝酸塩等)検出試薬。
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化粧品の成分用途
着色剤
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効能
診断補助薬 (膀胱鏡検査)
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商品名
インジゴカルミン (アルフレッサファーマ); インジゴカルミン (第一三共)
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説明
Indigo carmine is indigotindisulfonate sodium, a marker dye used during cystoscopy and ureteral catheterization.
(1) Indigo carmine is also used in endoscopic procedures, lymph node and vessel delineation, and for tumor localization. Indigo carmine is an unapproved drug without FDA approved labeling.
(2) There is no single dye that can replace indigo carmine. Choice of alternative agent will depend on type of procedure and physician discretion, as well as product availability.
Indigo Carmine (IC) is the most common chemical dye for clothes dyeing, which is considered as a refractory molecule since it is required a rather strong chemical treatment for its elimination from the water waste. The presence of this dye in residuals causes notorious change of water color and smell even in very low concentration. Moreover, if some of this water reaches natural streams it can be toxic for aquatic living entities due to the formation of toxic compounds such as aromatic amines.
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化学的特性
purple powder
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使用
Indigo Carmine (FD&C Blue #2) is a colorant. It has poor ph stability in that after 1 week at ph 3 and 5 it will appreciably fade, at ph 7 considerably fade, and at ph 8 fade completely. It is the least soluble of all food colors, with a solubility of 1.6 g in 100 ml of water at 25°c. Complete fading occurs in alkalis such as 10% sodium carbonate and 10% sodium hydroxide, with fading also occurring in 10% sugar systems. It has very poor light stability and oxidation stability, and moderate stability to heat; it has a deep blue hue with poor tinctorial strength. It is the only food color that has good resistance to reducing agents, but has very poor compatibility with food components. The major use is in pet food, but it is also used in candies, confections, and baked goods. The common name is indigotine.
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定義
ChEBI: An organic sodium salt resulting from the formal condensation of indigo carmine (acid form) with two equivalents of sodium hydroxide. It is an indicator at pH 11.5-14, changing from blue to yellow.
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製造方法
3H-indol-3-one,2-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,2-dihydro?with strong sulfuric acid or trace fuming sulfuric acid products.
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一般的な説明
Indigo to dark blue powder.
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空気と水の反応
Water soluble.
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反応プロフィール
Sensitive to light. Very sensitive to oxidizing agents. Color is readily discharged by nitric acid, chlorates, etc. Color of aqueous solutions fades on standing.
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火災危険
Flash point data for Acid Blue 74 is not available, but Acid Blue 74 is probably combustible.
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純化方法
Its solubility in H2O is 1g/100mL at 25o. It has been purified by dissolving in H2O, filtering and adding EtOH to cause the salt to separate. Wash the solid with EtOH, Et2O and dry in vacuo. [V.rlander & Schubert Chem Ber 34 1860 1901, UV: Smit et al. Anal Chem 27 1159 1955, Preisler et al. J Am Chem Soc 81 1991 1959, Beilstein 25 IV 1975.]
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参考文献
American Society of Health-system Pharmacist.
Journal of Environmental Protection, 2016, 7, 1693-1706
