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外観
無色～黄褐色, 澄明～微濁の液体
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定義
本品は、主としてソルビトール(*)及びソルビトール無水物のオレイン酸モノエステルに酸化エチレン約5モルを付加重合したもので、次の化学式で表される。
w＋x＋y＋z：平均5
参照表示名称：ソルビトール
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溶解性
熱水、エタノール及びアセトンに溶ける。
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用途
生化学分野における界面活性、乳化、分散剤。
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用途
乳化剤、分散剤、可溶化剤、洗浄剤。
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用途
乳化剤、分散剤、可溶化剤、洗浄剤等ですが、膜タンパク質の可溶化剤としても使用されます。
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化粧品の成分用途
変性剤、可溶化剤、乳化剤、香料
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効能
界面活性剤
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特長
イオン性界面活性剤と比較して、たんぱく質に対する作用が温和です。
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特長
動物由来の原料および遺伝子組換え原料を使用していません。
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特性
Tween 80, commercially known as Polysorbate-80, is a viscous, water-soluble Yellow to amber liquid derived from polyethoxylated sorbitan and oleic acid. Tween 80 is structurally similar to the (polyethylene) glycols and used both in injections (0.8-8.0%) and in oral suspension (0.375% w/v). A number of anticancer drugs can be formulated by Tween 80. Typical examples include etoposide and minor groove-binding cyclopropylpyrroloindole analogues like carzelesin.
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化学的特性
Tween 80 has a faint, characteristic odor and a warm, somewhat bitter taste. It is a mixture of oleate partial esters
of sorbitol and sorbitol anhydrides condensed with approximately 20 mole of ethylene oxide (C2H4O) for each mole of sorbitol and
its mono- and dianhydrides.
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使用
Tween 80 is the trade name of a detergent that can be useful in identifying mycobacteria that possess a lipase that splits the compound into oleic acid and polyoxyethylated sorbitol.
Tween 80 is used as an additive for cell culture media. It has numerous effects, e.g. increasing the transformation frequency of Brevibacterium lactofermentum or enhancing the secretion of acid and alkaline phosphatase by Neurospora crassa.
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定義
ChEBI: A polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by an oleoyl group.
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一般的な説明
Amber-colored viscous liquid. pH (5% aqueous solution) 5-7. Faint odor and bitter taste.
Polysorbate 80 (Tween 80) is a synthetic surfactant composed of fatty acid esters of polyoxyethylene sorbitan. Polysorbate 80 is usually available as a chemically diverse mixture of different fatty acid esters, with the oleic acid comprising?>?58% of the mix. However, the main component of polysorbate 80 is polyoxyethylene-20-sorbitan monooleate, which is structurally similar to polyethylene glycols. Polysorbate 80 has a molecular weight of 1309.7 Da and a 1.064 g/ml density[1].
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空気と水の反応
Water soluble.
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反応プロフィール
Tween 80 is incompatible with strong alkalis and oxidizers.
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火災危険
Tween 80 is probably combustible.
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薬物動態学
Polysorbate 80 (Tween 80) is rapidly removed from systemic circulation. The polysorbate 80 plasma concentration-time curve (AUC) in a patient administered an intravenous (IV) infusion of docetaxel 35 mg/m2 (polysorbate 80 1.75 g) showed a polysorbate 80 peak concentration of 304 μg/ml. The AUC for polysorbate 80 was 321.7 mg h/ml, with a short disposition half-life of 1.07 h and a total plasma clearance of 5.44 l/h. The distribution of polysorbate 80 at steady state was similar to the total blood volume (4.16 l), suggesting that polysorbate 80 circulates as large micelles and does not significantly distribute outside the central compartment. In vitro studies suggest that polysorbate 80 is metabolized by rapid carboxylesterase-mediated hydrolysis[1].
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安全性プロファイル
Moderately toxic by
intravenous route. Mildly toxic by ingestion.
Experimental reproductive effects.
Questionable carcinogen with experimental
tumorigenic data. Human mutation data
reported. An eye irritant. When heated to
decomposition it emits acrid smoke and
irritating fumes.
