知母皂苷BII
知母皂苷BII 性质
| 沸点 | 1033.6±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.43 |
| 闪点 | 573℃ |
| 溶解度 | DMF：30mg/mL； DMSO：30mg/mL；乙醇：微溶； PBS（pH 7.2）：5 mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 12.85±0.70(Predicted) |
知母皂苷BII 用途与合成方法
Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC 50 value of 15.5 μg/mL in the HL-60 cells.
Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time.
知母皂苷BII 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-N0812 | 1 mg | 304 | ||
| 2024-01-25 | HY-N0812 | 知母皂苷BII | 136656-07-0 | 5mg | 880 |
