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外観
うすい黄色～黄色～黄赤色透明液体
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用途
合成中間体、実験用発がん物質
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化学的特性
N-nitrosodi-N-propylamine is a yellow liquid.
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使用
N-Nitrosodi-n-propylamine is used in small quantities in laboratory research. It has no known commercial use (IARC 1978, ATSDR 1989, HSDB 2009).
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一般的な説明
Clear to pale yellow liquid.
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反応プロフィール
N-NITROSODI-N-PROPYLAMINE is a nitrated amine derivative. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
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健康ハザード
ACUTE/CHRONIC HAZARDS: Toxic.
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火災危険
Some may burn but none ignite readily. Containers may explode when heated. Some may be transported hot.
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安全性プロファイル
Confirmed carcinogen
with experimental carcinogenic,
neoplastigenic, tumorigenic data. Moderately
toxic by ingestion and subcutaneous routes.
An experimental teratogen. Human
mutation data reported. When heated to
decomposition it emits toxic fumes of NOx.
See also NITROSAMINES.
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職業ばく露
N-nitrosodi-N-propylamine is used in
the manufacture of plastics, resins, rubber, and synthetic
textiles. There is no evidence that N-nitrosodi-N-propylamine
exists naturally in soil, air, food, or water. Small
quantities of N-nitrosodi-N-propylamine are inadvertently
produced during some manufacturing processes; as an
impurity in some commercially available dinitroaniline
based weed killers, and during the manufacture of some
rubber products. However, according to Sax, some similar
N-nitroso compounds are formed in the environment and
absorbed from precursors in food, water, or air; from
tobacco; and from naturally occurring compounds.
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発がん性
N-Nitrosodi-n-propylamine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
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環境運命予測
Chemical/Physical. N-Nitroso-n-propylamine will not hydrolyze because it does not contain a
hydrolyzable functional group (Kollig, 1993).
At influent concentrations of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities were
24, 13, 7.4, and 4.0 mg/g, respectively (Dobbs and Cohen, 1980).
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輸送方法
UN3082 Environmentally hazardous substances,
liquid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous
hazardous material, Technical Name Required
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不和合性
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions.
Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides. Sensitive to UV light.
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廃棄物の処理
N-Nitrosodi-N-propylamine
may be destroyed by high temperature incineration in an
incinerator equipped with an nitrogen oxide scrubber.
Chemical treatment methods may also be used to destroy
N-nitrosodi-N-propylamine. These methods involve
(a) denitrosation by reaction with 3% hydrobromic acid in
glacial acetic acid; (b) oxidation by reaction with potassium
permanganate-sulfuric acid; or (c) extraction of the nitrosamine
from the waste using dichloromethane and subsequent
reaction with triethyloxonium tetrafluoroborate (TOEF).
Consult with environmental regulatory agencies for guidance
on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform
with EPA regulations governing storage, transportation,
treatment, and waste disposal.
