クリシン

外観

ごくうすい黄色〜褐色, 結晶性粉末〜粉末

定義

本品は、次の化学式で表される有機化合物である。

溶解性

ジメチルスルホキシドに可溶

解説

クリシン,淡黄色のりょう柱状晶．融点275 ℃．熱アルコール類，氷酢酸，アニリンに易溶，水にほとんど不溶，冷アルコール類，クロロホルム，エーテルに難溶．アルコール溶液は塩化鉄(Ⅲ)により褐紫色を呈する．λmax 270，329 nm(log ε 4.40，3.90)．
森北出版「化学辞典（第2版）

存在

クリシン，フラボンの一つ．遊離型としてヤナギ科ポプラPopulus nigra，P.pyramidalisの若い葉芽，マツ目ヒメコマツPinus parvifloraの心材などに，また，配糖体トリンギン(5-グルコシド)として，バラ科リンゴMalus sieboldiの樹皮に含まれる．

化粧品の成分用途

皮膚コンディショニング剤

説明

Chrysin is a natural flavonoid with antioxidant, anti-inflammatory, and anticancer properties. It blocks COX-2 gene expression, PGE2 production, and hydroxyl radical formation in LPS-induced RAW 264.7 cells. Chrysin inhibits insulin-induced HIF-1α expression (~50% at 10 μM) in human prostate cancer DU145 cells and blocks DU145 xenograft-induced angiogenesis in vivo. In a mouse model of ischemia/reperfusion injury, chrysin decreased pro-inflammatory gene expression and oxidative stress, resulting in a reduction of infarct volume and neurological defects.

化学的特性

beige powder or Pale yellow prismatic crystal (crystallized from methanol) with a melting point of 285°C. This substance is soluble in alkali hydroxide solution and acetone, slightly soluble in ether, ethanol and chloroform, insoluble in water.

定義

ChEBI: Chrysin is a dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7. It has a role as an anti-inflammatory agent, an antineoplastic agent, an antioxidant, a hepatoprotective agent, an EC 2.7.11.18 (myosin-light-chain kinase) inhibitor and a plant metabolite. It is a dihydroxyflavone and a 7-hydroxyflavonol.

Source

The main sources of chrysin are honey and propolis, of which the content of chrysin in honey is 5.3 mg/kg and that in propolis is 28 g/L. In addition, chrysin is also found in various vegetables, fruits, herbs, and even mushrooms. Another source of populin is an endophytic fungus Chaetomium globosum, which is related to Chaetomorpha media from India. In addition, chrysin exists in the form of glycosides in walnut, walnut skin, walnut flower and pericarp passion fruit, and in the form of 6-c-arabinoside-8-c-glucoside or glucuronic acid ester in Pinellia ternata.