Liposomal CoQ10 (L-CoQ10) is an endogenous cellular antioxidant, and although coenzyme q10 has not been approved as a drug by the U.S. Food and Drug Administration, it is widely used in dietary supplements[1]. Studies have shown that cosmetic applications of Coenzyme Q10 have demonstrated its ability to reduce photoaging and correspondingly reduce the depth of wrinkles[2]. In addition, L-CoQ10 supplementation may antagonise hepatotoxicity induced by acetaminophen (PCM) overdose by attenuating oxidative stress, inflammation and apoptosis[3].
[1] JOOYEON JHUN. Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting.[J]. PLoS ONE, 2020. DOI:10.1371/journal.pone.0241080.
[2] WEN-CHUAN LEE Tung H T. Preparation and characterization of liposomal coenzyme Q10 for in vivo topical application[J]. International Journal of Pharmaceutics, 2010. DOI:10.1016/j.ijpharm.2010.05.006.
[3] AHLAM ALHUSAINI . Liposomal coenzyme Q10 abates inflammation, apoptosis and DNA damage induced by an overdose of paracetamol in rat’s liver[J]. Journal of King Saud University - Science, 2022. DOI:10.1016/j.jksus.2022.102144.
