溴夫定
溴夫定 性质
| 熔点 | 165°C |
|---|---|
| 密度 | 1.7800 (rough estimate) |
| 折射率 | 1.6520 (estimate) |
| 储存条件 | Inert atmosphere,2-8°C |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 8.37±0.10(Predicted) |
| 颜色 | 米白色 |
| 水溶解性 | Soluble in water and methanol. |
| Merck | 14,1378 |
| InChIKey | ODZBBRURCPAEIQ-CXYVBZRVSA-N |
溴夫定 用途与合成方法
Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage.
At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia.
溴夫定 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-13578 | 溴夫定 | 69304-47-8 | 25mg | 350 |
| 2024-01-25 | HY-13578 | 溴夫定 | 69304-47-8 | 10mM * 1mLin DMSO | 385 |
