4-isopropylcyclohexanol (4-iPr-CyH-OH), a novel analgesic compound , which inhibited TRPV1, TRPA1, TRPM8, TRPV4 and ANO1, as well as mitigated capsaicin-induced pain-related behaviors in mice. Moreover, the absence of an agonist effect for 4-iPr-CyH-OH on these five channels may reduce side effects and dosages[1].
[1] Yasunori Takayama, M. Tominaga, H. Furue. “4-isopropylcyclohexanol has potential analgesic effects through the inhibition of anoctamin 1, TRPV1 and TRPA1 channel activities.” Scientific Reports (2017).
