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外観
白色の結晶
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定義
本品は、酢酸(*)の亜鉛塩であり、次の化学式で表される。
参照表示名称：酢酸
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溶解性
水に溶けやすく、エタノールにやや溶けにくい。
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用途
ファインセラミックスの製造原科。
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用途
キレート滴定標準液、有機合成触媒。
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化粧品の成分用途
皮膚保護剤、殺菌剤、収れん剤
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効能
解毒薬 (銅吸収阻害)
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商品名
ノベルジン (ノーベルファーマ)
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使用上の注意
純度は金属ベースで差数法によって算出したもので、重量又は容量分析等の化学的方法によるものではありません。使用目的により、正確な含量が必要な場合は、それらの方法によって測定する必要があります。
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化学的特性
Zinc acetate dihydrate Zn(C2H3O2)•2H2O is a Colourless or white efflorescent crystals; faint acetic acid odor; astringent taste; monoclinic crystals; density 1.735 g/cm3; loses water at 100°C; decomposes at 237°C; readily dissolves in water, 43g/100 mL at 20°C; soluble in alcohol.
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使用
Zinc acetate dihydrate is used in the preparation of layered Zn-arylphosphonates with potential application in sorption, ion exchange or catalysis and zinc sulfide nanoparticles coated on silica particles. It is used in dietary and medical applications. It is also used as lozenges for treating the common cold. It is used as a seeding material to grow zinc oxide nanorods on the microfibers of polyethylene terephthalate fabric. In addition, it finds application as wood preservation, production of other zinc salts, ethylene acetate manufacture, and an analytical reagent in various industries. As a plating inhibitor, it is used in nuclear power plant.
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調製方法
Zinc acetate is synthesized by reacting zinc oxide with glacial acetic
acid, with subsequent crystallization, separation by centrifugation,
and drying and milling of the crystals. No organic solvents are used
during the synthesis.
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一般的な説明
Structure of zinc acetate dehydrate is monoclinic with unit cell dimensions a=14.50, b=5.32 and c=11.02?.
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応用例（製薬）
Zinc acetate has been used as an excipient in a variety of
pharmaceutical formulations including topical gels, lotions, and
solutions, and subcutaneous injections. It has also been investigated
for use in an oral controlled-release formulation for water-soluble
drugs in combination with sodium alginate and xanthan gum.
Therapeutically, zinc acetate has been used in oral capsules for
the treatment of Wilson’s disease. Zinc acetate has also been
demonstrated to be effective as a spermicide in vaginal contraceptives.
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安全性
Zinc acetate is used in topical pharmaceutical formulations and
subcutaneous injections, where it is generally regarded as relatively
nontoxic and nonirritant when used as an excipient. However, zinc
acetate is poisonous by intravenous and intraperitoneal routes; it is
also moderately toxic following oral consumption.
LD50 (mouse, IP): 0.108 g/kg
LD50 (mouse, oral): 0.287 g/kg
LD50 (rat, IP): 0.162 g/kg
LD50 (rat, oral): 0.794 g/kg
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貯蔵
Zinc acetate loses water of hydration above 100℃. Zinc acetate
should be stored in an airtight container in a cool, dry, place.
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純化方法
It crystallises (in poor yield) from hot water or, better, from EtOH. [Beilstein 2 III 193, 2 IV 114.]
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不和合性
Zinc acetate is incompatible with oxidizing agents, zinc salts, alkalis
and their carbonates, oxalates, phosphates, and sulfides.
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規制状況(Regulatory Status)
Included in the FDA Inactive Ingredients Database (SC injections;
topical lotions and solutions). Included in medicines licensed in the
UK.
