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外観
暗紫赤色～暗赤紫色, 結晶性粉末～粉末
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定義
本品は、合成又は天然から得られるカロテノイド化合物であり、次の化学式で表される。
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溶解性
クロロホルムに溶け、エタノールに極めて溶けにくく、水にほとんど溶けない。
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用途
カロテン定量用標準品。
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化粧品の成分用途
皮膚コンディショニング剤、着色剤
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説明
α-Carotene is a precursor of vitamin A that has been found in various fruits and vegetables. It inhibits proliferation of GOTO human neuroblastoma cells more potently than β-carotene and halts the cell cycle at the G0/G1 phase concomitantly with a reduction in the mRNA expression of the protooncogene N-Myc. It is also more potent than β-carotene in mouse models of skin and lung carcinogenesis and decreases the number of hepatomas in mice with spontaneous liver carcinogenesis when administered in drinking water at a concentration of 0.05%. α-Carotene levels are increased in patients with coronary heart disease and are inversely correlated with the risk of estrogen receptor-negative breast cancer.
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使用
carotene is used to provide a red-orange color in cosmetic formulations. It is the primary yellow coloring component of butter, carrots, and egg yolk. Carotene is found in plants as well as in many animal tissues.
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一般的な説明
α-Carotene is a carotenoid, which shows anticarcinogenic activity.
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純化方法
Purify α-carotene by chromatography on columns of calcium hydroxide, alumina or magnesia. Crystallise it from CS2/MeOH, toluene/MeOH, diethyl ether/pet ether, or acetone/pet ether. Store it in the dark, under N2 or Ar at -20o. It gives a blue colour with max at 542nm when mixed with SbCl3 in CHCl3. [Karrer & Walker Helv Chim Acta 16 641 1933, Eugster et al. Helv Chim Acta 52 1729 1969, Eugster & Karrer Helv Chim Acta 38 610 1955, Strain J Biol Chem 105 523 1934, Beilstein 5 III 2457, 5 IV 2620.]
