4-アミノベンズアミジン·2塩酸塩

外観

白色～ほとんど白色粉末～結晶

化学的特性

white to yellowish fine crystalline powder

使用

4-Aminobenzamidine dihydrochloride is a synthetic diamidine derivative that acts as a urokinase inhibitor as well as trypsin inhibitor. It is used as a ligand in affinity chromatography for purification and immobilization of enzymes.

主な応用

4-Aminobenzamidine dihydrochloride can be used to synthesize:
Orally active fibrinogen receptor antagonists based on benzamidines.
Benzamidine derivatives that are selective and potent serine protease inhibitors.
Novel pyrrolo [3,2-c] quinolines that are structural analogs of topoisomerase inhibitors such as coralyne and fagaronine.
Synthesis of a selective inhibitor of PRMT1 (SKLB-639)

製造方法

4-Aminobenzamididine dihydrochloride is obtained by cyanation, addition, amination and reduction of 4-nitrobenzoic acid.