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外観
白色, 結晶性粉末～粉末
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定義
本品は、次の化学式で表される複素環式化合物である。
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溶解性
温水及び温エタノールに溶け、水及びエタノールにくい。
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解説
(2,5-dioxo-4-imidazolidinyl)urea．C4H6N4O3(158.12)．アラントインは，プリンが代謝されてできる化合物．プリン代謝でできた尿酸が，多くの哺乳類ではさらに尿酸オキシダーゼによって代謝されて，水に溶けやすいアラントインとなり排泄される．動物の尿中に多くあり，植物界からも多く見いだされている．プリンの代謝産物．尿酸を過マンガン酸カリウムで酸化するか，グリオキサール酸またはジクロロ酢酸を尿素と加熱して合成される．ラセミ体は融点238 ℃(分解)．冷水，冷エタノールに微溶．外傷の治癒促進に用いられる．[CAS 97-59-6] 森北出版「化学辞典（第2版）
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用途
薬理研究用(生長促進作用)。
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化粧品の成分用途
皮膚コンディショニング剤、皮膚保護剤
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効能
抗炎症薬, 外用傷薬
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説明
Allantoin is a product of purine and uric acid metabolism. It is formed through oxidation of uric acid by urate oxidase in most mammals but is formed only through non-enzymatic oxidation by free radicals in humans. Urinary levels of allantoin are increased prior to the onset of Alzheimer’s disease symptoms in mice expressing mutations in amyloid precursor protein and tau (APP/tau) but not during the early/middle stage of the disease, indicating its potential use as a biomarker for predicting Alzheimer’s disease onset. Due to the formation of allantoin by free radicals in humans, increased urinary levels are a potential biomarker for oxidative stress status.
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化学的特性
White Solid
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使用
allantoin is a botanical extract said to be healing, calming, and soothing, it can also help protect the skin from harmful external factors (e.g., wind burn). It is considered an excellent temporary anti-irritant and is believed to stimulate new tissue growth, helping heal damaged skin. Allantoin is appropriate for sensitive, irritated, and acne skins. Derived from the comfrey root, it is considered non-allergenic.
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定義
ChEBI: An imidazolidine-2,4-dione that is 5-aminohydantoin in which a carbamoyl group is attached to the exocyclic nitrogen.
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一般的な説明
Allantoin, the final catabolic product of purines in mammals, is a highly polar and amphoteric substance. Allantoin is mainly used for skin protection as the drug promotes cell proliferation and wound healing.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
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純化方法
It crystallises from water or EtOH [Hartman et al. Org Synth Coll Vol II 21 1943]. [Beilstein 25 III/IV 4071.]
