Fenazaquin is an acaricide mainly used for control of mites
(Eutetranychus, Panonychus and Tetranychus spp.) on pome and citrus
fruits and glasshouse-grown ornamental plants.
Fenazaquin is a non-systemic acaricide/insecticide used widely in controlling mites and other related pests in fruits, vegetables and tea.
Acaricide and insecticide.
ChEBI: Fenazaquin is a member of quinazolines. It has a role as an acaricide and a mitochondrial NADH:ubiquinone reductase inhibitor.
Fenazaquin is a lipophilic compound and hence is immobile in soils and is
not translocated in plants. The main pathways of metabolism involve
cleavage of the bridging group between the quinazoline and phenyl rings,
oxidation of the tert-butyl sustituent and of the heterocyclic portion of the
quinazoline ring and cleavage of that ring. Most of the information is
taken from a pamphlet produced by the manufacturer of the compound in
which full experimental details were not given (DowElanco, 1993).
Fenazaquin is hydrolysed under acidic conditions but the rate is slow
under neutral and alkaline conditions. Half-lives were 8,442 and 584 days
(22 °C) at pH values of 5, 7 and 9, respectively. Hydrolysis occurs by
cleavage of the ether linkage to form quinazolin-2-ol (2) and an alcohol
(3) as shown in Scheme 1. The major route of degradation in aquatic
environments is by photolysis, the main products (2 and 3) being formed
by cleavage of the ether lmkage and include the alkene (4) (DowElanco,
1993).
