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外観
無色～ほとんど無色透明液体
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定義
本品は、クエン酸(*)とブタノール(*)とのトリエステルであり、次の化学式で表される。
参照表示名称：クエン酸, ブタノール
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化粧品の成分用途
可塑剤、溶剤
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主な用途／役割
脂肪酸系可塑剤。主にPVCに使用。
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化学的特性
Tributyl citrate is a clear, odorless, practically colorless, oily liquid.
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使用
Tributyl Citrate, is a non-phthalate plasticizer, that can be used for the preparation of resins. It can also used for the synthesis of Acetyl Tributyl Cirate, a valuable biodegradable plasticizer of low toxicity, found in nail polish and other cosmetics.
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調製方法
Tributyl citrate is prepared by the esterification of citric acid with
butanol.
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一般的な説明
Tributyl citrate is an ester of citric acid. It is used to plasticize polymers for coating solid drug dosage forms, tablets and capsules.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
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応用例（製薬）
Tributyl citrate is used to plasticize polymers in formulated
pharmaceutical coatings. The coating applications include capsules,
tablets, beads, and granules for taste masking, immediate release,
sustained-release, and enteric formulations.
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安全性
Tributyl citrate is used in oral pharmaceutical formulations. It is
generally regarded as an essentially nontoxic and nonirritating
material. However, ingestion of large quantities may be harmful.
LD50 (cat, oral): >50 mL/kg
LD50 (mouse, IP): 2.9 g/kg
LD50 (rat, oral): >30 mL/kg
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貯蔵
Tributyl citrate should be stored in well-closed containers in a cool,
dry location at temperatures not exceeding 38℃. When stored in
accordance with these conditions, tributyl citrate is a stable
material.
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不和合性
Tributyl citrate is incompatible with strong alkalis and oxidizing
materials.
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規制状況(Regulatory Status)
Approved in the USA for indirect food contact in food films.
Included in the Canadian List of Acceptable Non-medicinal
Ingredients.
