ロシレチニブ

効能

抗悪性腫瘍薬

説明

CO-1686 is an irreversible kinase inhibitor that specifically targets mutant forms of the epidermal growth factor receptor (EGFR) including T790M (K_i = 21.5 nM) with significantly reduced activity at the wild-type form of the receptor (K_i = 303.3 nM). CO-1686 has been shown to inhibit the proliferation of non-small cell lung cancer (NSCLC) cells expressing mutant EGFR with GI₅₀ values ranging from 7-32 nM in vitro, inducing apoptosis. It also demonstrates anti-tumor activity in NSCLC EGFR mutant xenograft and transgenic models dosed orally at 100 mg/kg/day.

使用

CO 1686 is seen as an irreversible epidermal growth factor receptor (EFGR1) kinase inhibitor.