佐芬普利
佐芬普利 性质
| 熔点 | 129-131.5 °C(lit.) |
|---|---|
| 比旋光度 | D25 -36.5° (c = 1 in methanol) |
| 沸点 | 646.3±55.0 °C(Predicted) |
| 密度 | 1.34±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：5 mg/ml（11.64 mM） |
| 形态 | 结晶 |
| 酸度系数(pKa) | pK1:4.236 (25°C) |
| 颜色 | 浅黄色 |
| CAS 数据库 | 81872-10-8(CAS DataBase Reference) |
佐芬普利 用途与合成方法
IC50: 81 μM (ACE)
Kinetic analyses demonstrate that enalapril inhibits the uptake of GlySar in a competitive manner (K i approximately 6 mM). Fosinopril and Zofenopril have the greatest inhibitory potency (IC 50 values of 55 and 81μM, respectively) while the other ACE inhibitors exhibit low-affinity interactions with the renal peptide transporter.
Zofenopril, a sulphydrylic compound, at doses higher than 70 mg/kg i.p. produces significant protection (i.e. at 70 mg/kg, P=0.044, F=2.17, d.f.=18; at higher concentration P<0.05) against the tonic phase of the audiogenic seizure response. Pretreatment with Zofenopril (15 mg/kg, i.p.) is able to produce a consistent shift to the left of the dose-response curves and a significant reduction of ED 50 values against clonus of some AEDs with the exceptions of diazepam, felbamate, phenobarbital and phenytoin compare with concurrent groups, suggesting an increase in anticonvulsant activity.
佐芬普利 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-108321S | 1 mg | 2350 | ||
| 2024-01-25 | HY-108321 | 1-萘乙酸 | 81872-10-8 | 5mg | 1600 |
