トリブチルすずクロリド

外観

無色～黄色, 澄明の液体

溶解性

水で分解, エタノール, ベンゼンに易溶。ベンゼン, エタノールと混和する。水に不溶。

用途

ミトコンドリアの酸化的りん酸化阻害により、ATPaseを阻害する。

用途

環境分析用標準品

使用上の注意

不活性ガス封入

化学的特性

Colorless or light yellow clear liquid. Soluble in the common organic solvents; including alcohol, heptane, benzene, and toluene; insoluble in cold water, but hydrolyzes in hot water.

使用

Tributyltin Chloride is a triorganotin compound with insecticidal acitivity. It is an endocrine disruptor as well as an inhibitor for the V-ATPases (potential targets in the treatmen t of diseases such as osteoporosis and cancer). Tributyltin Chloride has the functions of antiseptic, sterilization and mildew proof and widely used in wood preservation, ship paint, etc. Further, it is used in hot end glass coating and rodent-repellent for cable coatings.

製造方法

Tributyltin chloride is prepared by a redistribution reaction by combining stannic chloride and tetrabutyltin:
3 (C4H9)4Sn + SnCl4 → 4 (C4H9)3SnCl.

危険性

A poison by ingestion and skin contact. A severe eye irritant. Tributyl tin compounds are extremely toxic to marine life.

毒性学

Tributyltin chloride (TBTCL) is a widely used biocide and heat stabiliser for PVC compositions. TBTCL has been detected in humans and may cause harmful effects on the thyroid, cardiovascular and other organs in humans. It is also an endocrine disruptor with toxic effects on the male reproductive system.TBTCL causes apoptosis and cell cycle arrest. Activation of endoplasmic reticulum stress and inhibition of autophagy are responsible for TBTCL-induced apoptosis and cell cycle arrest.