1,3-二咖啡酰奎宁酸
1,3-二咖啡酰奎宁酸 性质
| 沸点 | 819.9±65.0 °C(Predicted) |
|---|---|
| 密度 | 1?+-.0.1 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Sealed in dry,2-8°C |
| 溶解度 | 可溶5mg/mL，澄清，无色至浅黄色 |
| 酸度系数(pKa) | 2.50±0.50(Predicted) |
| 颜色 | 白色至类白色 |
| 稳定性 | 吸湿性 |
1,3-二咖啡酰奎宁酸 用途与合成方法
1,3-二咖啡酰奎宁酸是一种抗高脂血症的药物。此外，作为神经保护剂对抗淀粉样蛋白-β毒性治疗阿尔茨海默病。
1,3-Dicaffeoylquinic acid是咖啡酰奎宁酸衍生物，具有抗氧化活性和自由基清除活性。|
Akt
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PI3K
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1,3-Dicaffeoylquinic acid shows increased neuronal cell viability against Aβ(42) toxicity in a concentration-dependent manner in neurons. 1,3-Dicaffeoylquinic acid activates both phosphoinositide 3-kinase (PI3K)/Akt and extracellular regulated protein kinase 1/2 (Erk1/2) with stimulating their upstream tyrosine kinase A (Trk A). 1,3-Dicaffeoylquinic acid's anti-apoptotic potential is related to the enhanced inactivating phosphorylation of glycogen synthase kinase 3β (GSK3β) and the modulation of expression of apoptosis-related protein Bcl-2/Bax. 1,3-Dicaffeoylquinic acid (10 μM, 20 μM, 50 μM, and 100 μM) significantly increases cell viablity before OGD/reperfusion, and prevents the depletion of GSH under OGD/reperfusion insult. 1,3-Dicaffeoylquinic acid induces nuclear translocation of Nrf2 in OGD/reperfusion treated astrocytes, and induces increased GCL activity, and the effect is lost in Nrf2 siRNA-transfected cells.
1,3-Dicaffeoylquinic acid (32.0 mg/kg, p.o.) and 1-O-ABL are absorbed very quickly in Wistar rats. The maximum plasma concentrations for 1,3-Dicaffeoylquinic acid and 1-O-ABL are 44.5 ± 7.1 and 19.1 ± 6.9 ng/mL, respectively.
药理药效:具有氧化、抗炎、抗病毒、抗纤维化、抑制平滑肌收缩、降血脂等诸多作用。
