(2S)-2-氨基-2-[(1S,2S)-2-羧基环丙-1-基]-3-(吨-9-基)丙酸
(2S)-2-氨基-2-[(1S,2S)-2-羧基环丙-1-基]-3-(吨-9-基)丙酸
![(2S)-2-氨基-2-[(1S,2S)-2-羧基环丙-1-基]-3-(吨-9-基)丙酸 结构式](https://img.chemicalbook.com/CAS/GIF/201943-63-7.gif)
(2S)-2-氨基-2-[(1S,2S)-2-羧基环丙-1-基]-3-(吨-9-基)丙酸 性质
| 沸点 | 580.8±40.0 °C(Predicted) |
|---|---|
| 密度 | 1.432 |
| 储存条件 | Store at RT |
| 溶解度 | 溶解度有限，溶于DMSO |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 2.02±0.10(Predicted) |
(2S)-2-氨基-2-[(1S,2S)-2-羧基环丙-1-基]-3-(吨-9-基)丙酸 用途与合成方法
|
mGluR1a 7.8 μM (IC 50 ) |
mGluR2 21 nM (IC 50 ) |
mGluR3 14 nM (IC 50 ) |
mGluR4 22 μM (IC 50 ) |
mGluR5a 8.2 μM (IC 50 ) |
mGluR7 990 nM (IC 50 ) |
mGluR8 170 nM (IC 50 ) |
LY341495 (0.3, 1, and 3 mg/kg, i.p.) displays a lower level of discrimination in rats. LY341495 (3.0 mg/kg) decreases Dvl-2, pGSK-3α/β and β-catenin protein levels but Dvl-1, Dvl-3 and GSK-3α/β are unaffected in both the PFC and STR. LY341495 has the generally the opposite effect following acute and chronic administration compared to mGlu2/3 agonist, LY379268. LY341495 (3 mg/kg, i.p., 2.5 h) -induced c-Fos expression is not altered in either KO brain. LY341495 is almost inactive in the central extended amygdala [central nucleus of the amygdala, lateral (CeL) and bed nucleus of the stria terminalis, laterodorsal (BSTLD)] in mGluR3-KO mice.
(2S)-2-氨基-2-[(1S,2S)-2-羧基环丙-1-基]-3-(吨-9-基)丙酸 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-70059 | 1 mg | 500 | ||
| 2024-04-30 | HY-70059 | (2S)-2-氨基-2-[(1S,2S)-2-羧基环丙-1-基]-3-(吨-9-基)丙酸 | 201943-63-7 | 5mg | 1100 |
