Desvenlafaxine Succinate is a dual serotonin and norepinephrine
reuptake inhibitor (SNRI) that was approved for the
treatment of major depressive disorder (MDD) in the United
States in 2008. In order to improve the efficacy and
safety profile of venlafaxine, Wyeth discovered and developed
one of the major metabolites of venlafaxine, namely the
O-desmethyl metabolite (desvenlafaxine). Desvenlafaxine is
also being developed for the treatment of moderate to severe
vasomotor symptoms associated with menopause (i.e., hot
flashes and night sweats) and is also in phase III clinical trials
to study it’s effectiveness in treating fibromyalgia and
neuropathic pain.