磺丁基环糊精
磺丁基环糊精 性质
| 熔点 | 202-204°C (dec.) |
|---|---|
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | Soluble in water. Insoluble in acetone, methanol, chloroform. |
| 形态 | 固体粉末 |
| 颜色 | 白色至灰白色 |
| InChIKey | WHGYBXFWUBPSRW-CQFZCEJCNA-N |
磺丁基环糊精 用途与合成方法
磺丁基醚-β-环糊精钠，是一种新型药物制剂辅料，属于阴离子型高水溶性环糊精的一种磺酸基衍生物。它能很好地与药物分子包合形成非共价复合物，提高了药物的稳定性、水溶性、安全性并且有效的提高了药物分子的生物活性它的肾毒性小，能缓和药物溶血性，控制药物释放速率。
以β-环糊精和1,4-磺丁内酯为原料，通过向碱性水溶液中引入适量有机溶剂，增加了1,4-磺丁内酯的溶解度，提高了磺丁基醚-β-环糊精的合成收率；所得产品溶液经过超声透析，活性炭脱色，冷冻干燥等操作得到磺丁基醚-β-环糊精粉末产品。
Captisol (SBE-β-CD, Sulfobutylether-β-Cyclodextrin) 是一种新型的、化学修饰过的环糊精，具有比较好的稳定性和溶解性。SBE-β-CD is a chemically modified β-CD that is a cyclic hydrophilic oligosaccharide which is negatively charged in aqueous media. β-CD functioned is a solubilizer only at low concentrations, whereas SBE7-β-CD exhibits strong solubilizing effects over a wide concentration range.
20% SBE-β-CD in saline:
Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Dissolve 0.9 g of NaCl in 100 mL distilled water to make a clear 0.9% saline solution.
2. Measure 2 g of dry SBE-β-CD.
3. Dissolve 2 g of SBE-β-CD in 0.9% saline to make 10 mL with a 20% (w/v) concentration. These may require ultrasonic (20-40 kHz, 30 seconds, repeat 3 times) or heating (37°C for about 30 minutes). If precipitation is observed, the precipitates can be dissolved by heating to 37°C and vortexing before use.
磺丁基环糊精 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-17031 | 磺丁基-Β-环糊精 | 182410-00-0 | 500mg | 500 |
| 2024-04-30 | XW18241000001 | 磺丁基-Β-环糊精钠盐 | 100g | 716 |
