テトラメチルこはく酸ニトリル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H300：飲み込むと生命に危険

  H371：臓器の障害のおそれ

  H373：長期にわたる、または反復暴露により臓器の障 害のおそれ

• 注意書き

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

テトラメチルこはく酸ニトリル 価格

テトラメチルこはく酸ニトリル 化学特性,用途語,生産方法

• 外観

  白色～ほとんど白色粉末～結晶

• 用途

  複写機のトナーの重合触媒の副産物

• 化学的特性

  Colorless, solid; odorless. Insoluble in water.

• 使用

  2,2,3,3-Tetramethylsuccinonitrile is used in preparation of 4,5-Dihydro-1,2,3-triazole derivatives as Farnesyltransferase inhibitors.

• 一般的な説明

  White crystals.

• 空気と水の反応

  Insoluble in water.

• 反応プロフィール

  Nitriles, such as TETRAMETHYLSUCCINONITRILE, may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids. TETRAMETHYLSUCCINONITRILE can react violently with (LiAlH4 + H2O).

• 危険性

  Toxic by inhalation and skin contact. Headache, nausea, and central nervous system convulsions.

• 火災危険

  Flash point data are not available for TETRAMETHYLSUCCINONITRILE, but TETRAMETHYLSUCCINONITRILE is probably combustible.

• 安全性プロファイル

  Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. A human skin irritant and allergen. In the preparation of sponge rubber, an azo compound is used that decomposes to form tetramethylsuccinonitrile or TMSN. Rats exposed to a concentration of 90 ppm exhbit their first convulsion after 1.5-2 hours or less. Rats exposed to concentration of 5.5 pprn exhbited their first convulsions in 27-31 hours and were dead in 31-46 hours. Absorbed by skin. The fatal dose in humans is thought to be about 25 mg/kg of body weight. TSN is slowly detoxified by the body. This nitrile is different from other nitriles in that duosulfate is a poor antidote for intoxication. When heated to decomposition it emits toxic fumes of CNand NOx. See also NITRILES and CYANIDE.

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テトラメチルこはく酸ニトリル スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS)

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