酒石酸フェニンダミン

酒石酸フェニンダミン 化学特性,用途語,生産方法

• 効能

  抗アレルギー薬, H1受容体拮抗薬

• 化学的特性

  A white or almost white, voluminous powder.

• 使用

  Histamine H1 receptor antagonist; antihistamine.

• 一般的な説明

  Phenindamine tartrate,2,3,4,9-tetrahydro-2-methyl-9-phenyl-1H-indeno[2, 1-c]pyridine bitartrate, occurs as a creamy-white powder, usuallywith a faint odor and sparingly soluble in water (1:40). A 2%aqueous solution has a pH of about 3.5. It is most stable inthe pH range of 3.5 to 5.0 and is unstable in solutions of pH 7or higher. Oxidizing substances or heat may cause isomerizationto an inactive form.
  Structurally, phenindamine can be regarded as an unsaturatedpropylamine derivative, in that the rigid ring systemcontains a distorted, trans-alkene. Like the other commonlyused antihistamines, it may produce drowsiness and sleepiness;it may also cause a mildly stimulating action in somepatients and insomnia when taken just before bedtime.

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