セフプロジル

化学名:セフプロジル

CAS番号.92665-29-7

英語名:Cefprozil

CBNumberCB4739649

MFC18H19N3O5S

MW389.43

MOL File92665-29-7.mol

别名

cis-セフプロジル

セフプロジル

(6R,7R)-7-[(R)-2-アミノ-2-(p-ヒドロキシフェニル)アセチルアミノ]-8-オキソ-3-(1-プロペニル)-5-チア-1-アザビシクロ[4.2.0]オクタ-2-エン-2-カルボン酸

セフプロジル物理性質

融点	215-217°C (dec.)
沸点	803℃
比重(密度)	1.53±0.1 g/cm3(Predicted)
RTECS 番号	XI0339000
闪点	>110°(230°F)
貯蔵温度	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解性	DMF: 0.3 mg/ml; DMSO: 2.5 mg/ml; PBS (pH 7.2): 1.25 mg/ml
外見	Powder
酸解離定数(Pka)	2.92±0.50(Predicted)
水溶解度	10mg/mlでDMSOに可溶。水に不溶。
BCS Class	3
InChIKey	WDLWHQDACQUCJR-PBFPGSCMSA-N
SMILES	N12[C@@]([H])([C@H](NC([C@H](N)C3=CC=C(O)C=C3)=O)C1=O)SCC(C=CC)=C2C(O)=O
CAS データベース	92665-29-7(CAS DataBase Reference)

セフプロジル化学特性,用途語,生産方法

効能
抗生物質, 細胞壁合成阻害薬
説明
Cefprozil is a new orally active cephalosporin useful in the treatment of otitis media, uncomplicated skin and skin structure infections plus upper/lower respiratory tract infections. Although structurally similar to cefadroxil, its spectrum of antibacterial activity is comparable to cefaclor, but exhibits greater activity against S.aureus, S. epidermidis, Listeria monocytogenes, Streptococci, H. influenzae, Propionibacterium acnes. Clostridium perfringens and difficile.
化学的特性
Pale Yellow Solid
使用
Semisynthetic oral cephalosporin consisting of approx. 90:10 Z/E isomeric mixture. Antibacterial
定義
ChEBI: A semisynthetic, second-generation cephalosporin, with prop-1-enyl and (R)-2-amino-2-(4-hydroxyphenyl)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is used to treat bronchitis as well as ear, skin and other bacterial infec ions.
抗菌性
Activity against Gram-positive cocci and Gram-negative bacilli is better than that of cefadroxil (which it structurally resembles) but is not as good as that of group 5 agents . It is moderately stable to hydrolysis by the common plasmid-mediated β-lactamases, but is hydrolyzed by the chromosomal enzymes of Gram-negative bacilli .
危険性
Moderately toxic by ingestion. Human sys- temic effects.
臨床応用
Cefprozil (Cefzil) is an orally active second-generationcephalosporin that is similar in structure and antibacterialspectrum to cefadroxil. Oral absorption is excellent (oralbioavailability is about 95%) and is not affected by antacidsor histamine H2-antagonists. Cefprozil exhibits greater invitro activity against streptococci, Neisseria spp., and S. aureusthan does cefadroxil. It is also more active than thefirst-generation cephalosporins against members of theEnterobacteriaceae family, such as E. coli, Klebsiella spp., P. mirabilis, and Citrobacter spp. The plasma half-life of1.2 to 1.4 hours permits twice-a-day dosing for the treatmentof most community-acquired respiratory and urinary tractinfections caused by susceptible organisms.
副作用
It is well tolerated. Diarrhea and gastrointestinal discomfort may occur. There have been a few reports of pseudomembranous colitis and serum sickness-like reactions.

セフプロジル上流と下流の製品情報

セフプロジル生産企業

セフプロジルスペクトルデータ(MS)

92665-29-7, セフプロジルキーワード

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セフプロジル

セフプロジル 化学特性,用途語,生産方法

セフプロジル 上流と下流の製品情報

セフプロジル 生産企業

セフプロジル スペクトルデータ(MS)

92665-29-7, セフプロジル キーワード

セフプロジル化学特性,用途語,生産方法

セフプロジル上流と下流の製品情報

セフプロジル生産企業

セフプロジルスペクトルデータ(MS)

92665-29-7, セフプロジルキーワード